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METRIMA-M
Vaginal Tablets
FORMULA: For vaginal tablets.

    Metronidazole ....................................... .500mg
    .......................................... Clotrimazol 100mg
    Excipients .................................... 1 member

PROPERTIES PHARMACOLOGY:

The set Fharmacodynamic:

Metronidazole:
Metronidazole is a derivative of 5 - nitro - imidazole, has broad activity on protozoa like amoeba, Giardia and on anaerobic bacteria.

Metronidazole is a drug for the treatment of protozoa like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Metronidazole bactericidal effect on Bacteroides, Fusobacterium and anaerobic bacteria other compulsory, but has no effect on aerobic bacteria. Metronidazole resistance only in a few cases. Trichomoniasis vaginalis can be treated with oral metronidazole or topical. Both women and men are to be treated, because men can carry disease without symptoms. In many cases combination therapy vaginal suppository and tablets. When inflamed cervical/vaginal bacteria, metronidazole will cause vaginal microbial flora back to normal in the majority of patients using the drug: metronidazole no impact on the normal bacterial flora in the vagina.

Clotrimazol:
Clotrimazol is a broad-spectrum antifungal agent used to treat the skin disease cases caused by infection with the fungus that causes various diseases and also has an effect on Trichomonas, Staphylococcus and Bacteroides. No effect with Lactobacilli.

Mechanism of action of clotrimazol is associated with phospholipids in the membrane fungi, alters the permeability of the membrane, causing the loss of essential intracellular destruction leads to fungal cell.

Invitro, clotrimazol have the effect of containing and fungicidal, depending on the concentration, the strains of Trichophyton Rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis and Candida types.

Natural resistance to clotrimazol. Only one strain of Candida isolates resistant guilliermondi clotrimazol. Cross-resistance among common azol.

Pharmacokinetic properties:
Metronidazole:
The level of drug exposure (area under the curve AUC) as the only disposable vaginal metronidazole gel 5g (approximately 37.5 mg) by approximately 4% AUC 500 mg oral metronidazole once (4977 nanograms - hours / ml and 125 000 nanograms - hours / ml). Comparing the AUC on the basis of 2 mg mg with a solution proves that the absorption of warehouse use metronidazole vaginal if only half the dose equal bending.

Clotrimazol:
Using applied to the skin or vaginal administration, clotrimazol very little is absorbed:

After vaginal tablets clotrimazol - 14C 100 mg, peak plasma concentrations averaging only 0.03 micrograms equivalent clotrimazol / ml after 1-2 days and about to slag 0.01 micrograms / ml after 8-24 hours if 5g cream solution clotrimazol - 14C 1%.

POINT:
Inflammation of the cervix, vaginal infections and inflammation of the vulva - vaginal infection caused by Trichomonas vaginalis with candida or bacteria.

CONTRAINDICATED:
    Patients with hypersensitivity to any component of the medication.
    Special Precautions and warnings when using the drug;

     Do not use concurrently with oral metronidazole.

     If there is irritation or sensitization when the solution should be discontinued and appropriate treatment.

     Must therapy enough time although the symptoms are relieved. After 4 weeks of treatment, if not better to the doctor again.

     Tell the physician if they showed increasing irritation, signs of hypersensitivity.

     Avoid sources of infection or reinfection.

     Precautions for pregnant women and nursing mothers.

INTERACTIONS WITH DRUGS:
Clotrimazol:
Tacrolimus in serum concentrations of liver transplant patients increase when administered concomitantly with clotrimazol. Therefore, tacrolimus dose should be reduced on demand.

Metronidazole:
Disulfiram Metronidazole works. So do not use this medicine at the same time 2 to avoid toxic effects on nerve as psychosis, confusion.
Concurrent use of metronidazole and metronidazole phenobarbital increase metabolism should metronidazole faster elimination.

Use metronidazole for patients who had high blood levels of lithium in (by taking lithium) will make serum lithium levels rise, toxic.

Metronidazole enhance the effect of a muscle relaxant veruronium no depolarization.

PREGNANCY AND LACTATION:
Insufficient research data on pregnancy in the first 6 months. This drug is used for the first 6 months of pregnancy when clearly indicated by your doctor and be monitored carefully.

Metronidazole is secreted in breast milk rapidly, breastfeeding can have the drug concentration in plasma by 15% of maternal concentrations. Breastfeeding should be discontinued during treatment with metronidazole.

NO DRIVING AND OPERATING MACHINERY: No impact

ADVERSE EFFECTS OF THE DRUG:
Metronidazole and clotrimazol not be absorbed by the body does not cause systemic adverse effects. Sometimes it may cause local irritation, in this case need to stop taking it.
Inform your doctor unwanted effects encountered when using the drug.

Overdose and Treatment:
Symptoms include nausea, vomiting and ataxia. Neurotoxic effects include convulsions, peripheral neuritis.

Treatment: No specific antidote. Symptomatic treatment and support

DOSAGE AND ADMINISTRATION:
Every day before going to bed put one party.

Usage: 1 capsule embedded boiled water for about 20 seconds, set deep in the vagina at night before bed, legs slightly reunited, ready to use within 7 days.

PRESENTATION: Box of 1 blister x 10 tablets vaginally.

STORAGE: cool and dry place, protected from light, temperature below 300C.

SHELF LIFE: 36 months from date of manufacture.

- Vaginal Tablets METRIMA-M met the TCCS.

- Keep far away from kids. Carefully read the manual before use.

- If you need further information, please consult your doctor.

- This drug is used under a physician's prescription.

       - Production at Plant No. 930 WHO-GMP C2, C Street, Cat Lai Industrial Zone, District 2, HCMC.